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The expanding role of GLP 1 receptor agonists: a narrative review of current evidence and future directions eClinicalMedicine What are GLP 1 Receptor Agonists and How Do They Work? SheMed Blog GLP 1 receptor agonists are increasingly used to treat type 2 diabetes and obesity, and trials have shown reductions in cardiovascular risk and slowing of kidney failure. Adverse events are mostly gastrointestinal. GLP 1 medicines started with injectable GLP 1RAs, then moved to oral peptides, and now co agonists. The future will usher in multiple new ways of delivering GLP 1 medicines, and activating GLP 1R signaling pathways, promising Combination SGLT2, GLP 1 therapy lowers risk for adverse CV outcomes in type 2 diabetes
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