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From GLP 1s to Lifelong Habits, Amy's Story. Stay Fit Mom Wellness Wednesday GLP 1 medications were originally developed for diabetes but researchers discovered something unexpected during clinical trials. Patients weren't just improving their blood sugar.They were losing weight. That discovery Insights into the Roles of GLP 1, DPP 4, and SGLT2 at the Crossroads of Cardiovascular, Renal, and Metabolic Pathophysiology Beyond GLP 1 Agonists: An Adaptive KetogenicMediterranean Protocol to Counter Metabolic Adaptation in Obesity Management Three major reviews commissioned by the World Health Organization find that while GLP 1 drugs can lead to substantial weight loss, researchers caution that most trials were funded by drugmakers, long term safety data