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does tirzepatide cause bone loss Tirzepatide, a dual GLP-1 and GIP receptor agonist, promotes bone loss in obese mice via gut microbial-related metabolites

Marsoni M251S
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4.0 ★★★★★
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Nae
Massapequa, US
★★★★★ 1
Smells too strong
Size: 5 in
My dog hates the way this thing smells. She tries to play with it, but the scent is too strong for her nose. I know it's the scent because she usually sniffs it two or three times in between trying to grab it with her mouth. She treats it like an explosive in her mouth and quickly moves away after spitting it out. She used to have a bone that looked similar to this (same material) that was unscented and she gnawed the hell out of it. My sister's pitbull spent the night and chewed that toy into bits, leaving my Yorkie mourning the loss of her once treasured bone. Please make an UNSCENTED version of this toy!!!!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 23, 2023
T
Verified Purchase
Tamara L.
Omaha, US
★★★★★ 5
Worth the money for heavy chewers
Color: Brown-X
I finally found a dog chew that my puppy can't destroy in a half an hour or less. My puppy loves this, chews on it for hours and still holding up.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 10, 2026
M
Verified Purchase
MM
Massapequa, US
★★★★★ 5
Holds up to a
Color: Brown-O
Bought this because of other positive reviews. It does hold up to an aggressive chewer but the pieces are sharp once it’s “broken in”. I bought the circular one as I figured that one would be less likely to break. It is still good after about 6 weeks.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on December 22, 2025
K
KO
San Leandro, US
★★★★★ 4
My dog didn’t take to it, but yours might.
Color: Brown-O
This is a very durable toy that’s reasonably priced. For some reason, my dog didn’t take to it. It might be the round shape, but there’s nothing wrong with the product. The size is good for large dogs. My dog is 50 pounds and there’s a chance it was too big for him. I’m not sure. But I think if your dog has enjoyed other similar toys, this is a good buy.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on August 15, 2025
B
Verified Purchase
B. Ferrante
West Palm Beach, US
★★★★★ 5
Fun and practical for our power chewer
Color: Brown-O
Four paws up! It is great for chewing and for rolling in a fetch game. Our powerful chewer loves it!
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Reviewed in the United States on October 23, 2025

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