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Structures of natural exendin-4, GLP-1 and several GLP-1 peptide drugs....
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Tirzepatide (TZP) is a 39-amino acid peptide composed of both native
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GLP-1 receptor agonists got their start in an unlikely place: the mouth of a lizard. A peptide that was discovered in Gila monster saliva, called exendin-4, was found to mimic the action
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Exendin-4 induced retching-like behavior mediated by postsynaptic effect via AMPA receptors in the area postrema of mice | American Journal of Physiology-Endocrinology and Metabolism
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Amino acid sequence of tirzepatide in comparison to native GIP, GLP-1,
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Exendin-4
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Frontiers
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