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foxo4-dri protocol FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation

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4.6 ★★★★★
Based on 394 reviews
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K
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KD
San Leandro, US
★★★★★ 5
Not long lasting, but preferred by my dogs and not smelly
Flavor Name: Chicken, Size: 12 Ounce (Pack of 1)
I have two pretty serious chewers. They prefer these bones over all of their longer-lasting dog bones, and these don't stink (which is more than I can say for most dog bones they like). I'm also less worried about digestion and choking hazards since these are rawhide-free. I buy these bones regularly and will continue to do so - just don't expect them to last more than a few minutes for big chewers.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on September 15, 2018
B
Verified Purchase
Brit
Bozeman, US
★★★★★ 5
My lab loves them!!
Flavor Name: Chicken, Size: 12 Ounce (Pack of 1)
I am not a fan of the price and I don't know why they are so pricy, but my lab lives them so I will treat him every once in awhile. I love that these take awhile for him to eat giving him more time to enjoy them.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 27, 2021
J
Verified Purchase
Jacob
Louisville, US
★★★★★ 4
Dog approved!
Flavor Name: Chicken, Size: 12 Ounce (Pack of 1)
My dog, a half pit bull and half chocolate lab, has a very sensitive stomach. With that in mind I have to always be wary of the things I buy her. With that in mind these seemed to work great! They don’t last as long as normal raw hide, so there is less “chew time” but she was excited when she received them! If your looking for a quick treat or reward for your dog these are great! If your looking for a bone/chewing alternative then these don’t quite meet that requirement.
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Reviewed in the United States on October 29, 2018
R
Verified Purchase
Rachierach
Port Orchard, US
★★★★★ 5
Doberman Approved
Flavor Name: Chicken, Size: 12 Ounce (Pack of 1)
My 106lb Doberman refuses to eat anything but these and duck hearts- go figure- he does not like any type of carb, his diet consists of Taste of the Wild and boiled chicken, he gets one of these every night and wiggles his cute little butt off when he hears me getting the bag, he can hardly contain his excitement. He has NEVER had any issues of chocking or vomiting with these, I am a huge believer in sharing experiences when it comes to our fur babies, mine loves his biscuit (that's what we call it" I know it isn't a biscuit.
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Reviewed in the United States on September 29, 2020
D
Verified Purchase
danaz
Los Angeles, US
★★★★★ 5
Great alternative to rawhide!
Flavor Name: Chicken, Size: 12 Ounce (Pack of 1)
We have been getting these for quite some time for our black lab. He eats rawhide too quickly and ends up regurgitating it all over the floor. So, on the advice of our vet, we tried something else. We tried these after many other products. These are gone as quickly as rawhide (with my dog, that's 10 minutes... TOPS!), but he doesn't have the digestive issues. The fact that they chew up similar to rawhide is a big plus, since I don't like it when he can't finish it in one sitting - that's just a yucky mess laying around on the floor. I highly recommend these SmartBones for anyone whose dog can't digest rawhide well.
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Reviewed in the United States on January 9, 2014

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